GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7665090 | 1 | rs11724614 | chr4:103550248 | MANBA | chr4:103552644-103682151:- | 0.21 | 5.5 | 4.83E-8 | Primary biliary cirrhosis |
| BRCA | cis | rs76419734 | 1 | rs11724839 | chr4:106638256 | INTS12 | chr4:106603787-106629881:- | -0.3 | -3.63 | 0.000301 | Post bronchodilator FEV1 |
| BRCA | cis | rs76419734 | 1 | rs11724884 | chr4:106677384 | INTS12 | chr4:106603787-106629881:- | -0.31 | -3.85 | 0.000125 | Post bronchodilator FEV1 |
| BRCA | cis | rs867186 | 1 | rs117249133 | chr20:33773630 | PROCR | chr20:33758727-33765164:+ | -0.25 | -4.84 | 1.5E-6 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs1364989 | 1 | rs11725470 | chr4:55006128 | FIP1L1 | chr4:54243820-54326102:+ | -0.16 | -3.45 | 0.00058 | Lupus nephritis in systemic lupus erythematosus |
| BRCA | cis | rs76419734 | 1 | rs11726124 | chr4:106766496 | INTS12 | chr4:106603787-106629881:- | 0.27 | 3.45 | 0.000577 | Post bronchodilator FEV1 |
| BRCA | cis | rs76419734 | 1 | rs11726569 | chr4:106606608 | INTS12 | chr4:106603787-106629881:- | -0.28 | -3.48 | 0.000517 | Post bronchodilator FEV1 |
| BRCA | cis | rs76419734 | 1 | rs11727189 | chr4:106619140 | INTS12 | chr4:106603787-106629881:- | -0.28 | -3.48 | 0.000517 | Post bronchodilator FEV1 |
| BRCA | cis | rs76419734 | 1 | rs11727348 | chr4:106679848 | INTS12 | chr4:106603787-106629881:- | -0.31 | -3.82 | 0.00014 | Post bronchodilator FEV1 |
| BRCA | cis | rs7665090 | 1 | rs11727546 | chr4:103557664 | MANBA | chr4:103552644-103682151:- | 0.22 | 5.64 | 2.2E-8 | Primary biliary cirrhosis |
| BRCA | cis | rs76419734 | 1 | rs11727745 | chr4:106716527 | INTS12 | chr4:106603787-106629881:- | -0.3 | -3.86 | 0.000121 | Post bronchodilator FEV1 |
| BRCA | cis | rs7694379 | 1 | rs11727803 | chr4:88213158 | HSD17B11 | chr4:88257691-88312455:- | 0.11 | 4.06 | 5.23E-5 | Platelet count |
| BRCA | cis | rs7694379 | 1 | rs11727835 | chr4:88213244 | HSD17B11 | chr4:88257691-88312455:- | 0.11 | 4.08 | 4.92E-5 | Platelet count |
| BRCA | cis | rs1061377 | 1 | rs11727875 | chr4:39135319 | KLHL5 | chr4:39046659-39123828:+ | -0.14 | -4.51 | 7.36E-6 | Uric acid levels |
| BRCA | cis | rs76419734 | 1 | rs11728044 | chr4:106604786 | INTS12 | chr4:106603787-106629881:- | -0.28 | -3.48 | 0.000517 | Post bronchodilator FEV1 |